the present study underscores the importance of examining associations between dhea concentrations and anxiety in longitudinal designs. additionally, lower dhea in response to an acute social stressor was found to be associated with increased negative mood during and after the stressor in a sample of undergraduate men (izawa et al., 2008). the present study sought to examine associations between salivary dhea concentrations and anxiety symptoms and diagnoses during the pubertal period. screen for child anxiety related disorders (scared): the scared is a 41-item parent- and self-report inventory that screens for symptoms of anxiety in children. the mean intra-assay coefficient of variation for dhea was 5.6% and the mean inter-assay coefficient of variation was 8.2%. associations between salivary hormone concentrations and time of day of the testing session were also examined to account for diurnal rhythms in hormone secretion.
next, correlations were conducted to examine associations between hormone concentrations, pds scores, menarche status, time of day, and anxiety disorder status, and a logistic regression was conducted to examine associations between dhea and anxiety disorder status while controlling for pds scores. thus, greater dhea was associated with increased anxiety symptom counts, even when controlling for testosterone concentrations and pubertal development (i.e., pds scores).2 next, we conducted two stepwise regressions with dhea as the dependent variable to examine which anxiety symptom domains might best predict concentrations of dhea in adolescence. the present study examined associations between salivary hormone concentrations and anxiety symptoms and diagnoses during the pubertal period in a relatively large sample of girls. results in the full sample indicated that greater dhea was associated with increased self-reported anxiety symptoms and increased anxiety symptoms on the k-sads clinical interview—results that remained even when controlling for salivary testosterone concentrations, pubertal status, menarche status, and time of day. first, as a limitation of the present study, we did not examine longitudinal associations between anxiety and dhea over adolescence. in conclusion, the present study examined associations between salivary dhea concentrations and anxiety symptoms and diagnoses during the pubertal period while controlling for salivary testosterone concentrations and pubertal development and found that greater salivary dhea concentrations were associated with increased self-reported anxiety symptoms, increased anxiety symptom counts based on the k-sads interview, and increased probability of an anxiety disorder. 5when participant age was substituted for pds scores in the regressions predicting scared total scores, anxiety disorder status, and anxiety symptom counts, dhea remained a significant predictor (all ps < .05) of scared scores, anxiety disorder status, and anxiety symptom counts, while age was not significantly associated with scared scores, anxiety disorder status, or anxiety symptom counts (all ps > .10).
dhea increases following acute mental stress, whatever the type and duration of mental stress. thus, we aimed to conduct a systematic review and meta-analysis to demonstrate that dhea levels could be a relevant biomarker of stress by summarizing all studies reporting dhea levels in acute mental stress conditions. ], and the characteristics of stress (type and duration). we described our results by calculating the effect size (es; standardized mean differences, smd) of the increase in dhea levels following acute stress (31). dhea measures and acute stress were the inclusion criteria of the 14 studies (table 1). all studies assessed the dhea levels at baseline and after acute stress (13–15, 34–44). figure 5. meta-analysis on dehydroepiandrosterone (dhea) changes between the first measure after the end of stress and baseline, stratified by type of acute stress (mental or exercise). particularly, dhea levels increased following acute mental stress (smd = 2.04, 95%ci = 1.43–2.65), whatever the type and duration of mental stress. furthermore, the capacity to increase the dhea levels in response to acute psychosocial stress also declines with age (14). finally, the main covariable influencing the increase of dhea levels following acute stress was obesity—individuals with higher bmi experience higher dhea response to an acute stress. the dhea levels increased following acute mental stress, whatever the type and duration of mental stress. all authors have read and agreed to the published version of the manuscript and gave final approval for the eligibility of all articles included in the analysis and provided critical revision of the article. mental health circumstances among health care workers and general public under the pandemic situation of covid-19 (home-covid-19).
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dhea, a steroid hormone that surges in adolescence, has been previously linked to anxiety, although the direction of this effect has been mixed. conclusions: dhea is a biomarker of acute stress, with a short-term increase (1 h). dhea increases following acute mental stress, whatever the in previous studies, serum dhea and cortisol levels have been found to be higher in patients with anxiety disorders such as panic disorder, how to treat high dhea levels, high dhea symptoms female, high dhea symptoms female, high dhea and stress, high dhea-s levels in females.
greater dhea was associated with increased self-reported anxiety symptoms. greater dhea was linked to increased probability of current anxiety diagnoses. dhea was associated with anxiety when controlling for gonadal hormones and puberty. among all anxiety disorders, gad symptoms were most robustly correlated with dhea. may cause agitation, delusions, nervousness, irritability, or psychosis and may induce hypomanic, aggressive, psychotic, or disinhibited behavior. in people with bipolar disorder, dhea should be used with caution and only in low doses because it can exacerbate mania, irritability, and aggression. anxiety is another one of the symptoms of high dhea levels. because of the aggressive nature that testosterone and dhea can bring about at according to information in the article, dehydroepiandrosterone-s (dhea-s) is a hormone produced by the adrenal glands and is believed to be several evidences suggest that increasing concentrations of dhea-s attenuates anxious and depressive symptomatology, showing that dhea-s, dhea anxiety reddit, dhea and cortisol relationship.
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